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A 784168

Cat. No. 4319 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective TRPV1 antagonist
化学名： 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 784168

A 784168 is a potent TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin). Displays no activity against a range of receptors, including TRPA1, GABA, opioid, and purinergic receptors.

化合物库 for A 784168

A 784168 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 784168

分子量 479.4
公式 C19H15F6N3O3S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 824982-41-4
PubChem ID 11420211
InChI Key SDUAWRFBHRAFBM-UHFFFAOYSA-N
Smiles O=C(NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3)C(CC2)=CCN2C1=C(C(F)(F)F)C=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 784168

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.94 100
ethanol 23.97 50

制备储备液 for A 784168

以下数据基于产品分子量 479.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.43 mL 20.86 mL
5 mM 0.42 mL 2.09 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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产品说明书 for A 784168

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for A 784168

参考文献是支持产品生物活性的出版物。

Bianchi et al (2007) [3H]-A-778317 [1-((R-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 323 285 PMID: 17660385

Cui et al (2006) TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J.Neurosci. 26 9385 PMID: 16971522

If you know of a relevant reference for A 784168, please let us know.

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关键词: A 784168, A 784168 supplier, A784168, trpv1, transient, receptor, potential, vanilloids, antagonists, potent, selective, TRPV, 4319, Tocris Bioscience

2 篇 A 784168 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 784168 的部分引用包括：

Alharris et al (2019) Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget 10 45 PMID: 30713602

James et al (2022) Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels. Nat Commun 13 600 PMID: 35140203

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