A 803467

Cat. No. 2976 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective Na_V1.8 channel blocker

化学名： 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide

纯度： ≥98% (HPLC)

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for A 803467

A 803467 is a selective blocker of Na_V1.8 channels (IC₅₀ values are 8, 2450, 6740, 7340 and 7380 nM for hNa_V1.8, hNa_V1.3, hNa_V1.7, hNa_V1.5 and hNa_V1.2 channels respectively). Shows no significant activity against TRPV1, P2X_2/3, Ca_V2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

化合物库 for A 803467

A 803467 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 803467

分子量	357.79
公式	C₁₉H₁₆ClNO₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	944261-79-4
PubChem ID	16038374
InChI Key	VHKBTPQDHDSBSP-UHFFFAOYSA-N
Smiles	ClC(C=C2)=CC=C2C1=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 803467

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	35.78	100
	ethanol	8.94	25

制备储备液 for A 803467

以下数据基于产品分子量 357.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL
10 mM	0.28 mL	1.4 mL	2.79 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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产品说明书 for A 803467

分析证书/产品说明书

化学品安全技术说明书

参考文献 for A 803467

参考文献是支持产品生物活性的出版物。

Rush (2007) Painful research: Mol.Interv. 192 et al (2008) Discovery J.Med.Chem. 407 identification of a small-molecule inhibitor that selectively targets Na_V1.8 sodium channels. 7 PMID: 17827438

ght">McGaraughty NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. 324 PMID: 18089840

ght">Kort and biological evaluation of 5-Aryl-2-furfuramides, potent and selective blockers of the Na_v1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. 51 PMID: 18176998

ght">Jarvis a potent and selective Na_V1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. 104 PMID: 17483457 you know of a relevant reference for A 803467, please let us know.

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关键词: A 803467, A 803467 supplier, Selective, NaV18, blockers, Sodium, Channels, voltage-gated, voltage-dependent, Na+, A803467, Voltage-gated, 2976, Tocris Bioscience