Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewA 844606
Discontinued Product
4477 has been discontinued.
说明： Selective α7 nAChR partial agonist
化学名： 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
纯度： ≥99% (HPLC)
生物活性 for A 844606
A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.
技术数据 for A 844606
| 分子量 | 320.38 |
| 公式 | C20H20N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 861119-08-6 |
| PubChem ID | 11461365 |
| InChI Key | WUJHMDPPANTBTQ-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C=CC(N4CC(CN(C)C5)C5C4)=C3)OC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 844606
参考文献 for A 844606
参考文献是支持产品生物活性的出版物。
Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054 PMID: 18157163
按产品操作查看相关产品
关键词: A 844606, A 844606 supplier, A844606, nicotinic, acetylcholine, receptors, alpha7, a7, agonists, nAChR, α7, Nicotinic, (a7), Receptors, 4477, Tocris Bioscience
A 844606 的评论
目前没有该产品的评论。 Be the first to review A 844606 and earn rewards!
Have you used A 844606?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.