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A 887826

Cat. No. 4249 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent voltage-dependent NaV1.8 channel blocker
化学名： 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 887826

A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

化合物库 for A 887826

A 887826 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 887826

分子量 480.99
公式 C26H29ClN4O3
储存 Store at RT
纯度 ≥97% (HPLC)
CAS Number 1266212-81-0
PubChem ID 46919335
InChI Key JPJGFWKHSMUKFO-UHFFFAOYSA-N
Smiles ClC1=C(OCCCC)C=CC(C2=CN=CC(C(NCC3=CC=CN=C3N4CCOCC4)=O)=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 887826

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.05 50

制备储备液 for A 887826

以下数据基于产品分子量 480.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.16 mL 20.79 mL 41.58 mL
2.5 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.42 mL 2.08 mL 4.16 mL
25 mM 0.08 mL 0.42 mL 0.83 mL

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参考文献 for A 887826

参考文献是支持产品生物活性的出版物。

Zhang et al (2010) A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Neuropharmacology 59 201 PMID: 20566409

If you know of a relevant reference for A 887826, please let us know.

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关键词: A 887826, A 887826 supplier, A887826, sodium, channel, blocker, blocks, NaV1.8, voltage-dependent, ion, channels, antiallodynic, Voltage-gated, Sodium, Channels, 4249, Tocris Bioscience

1 篇 A 887826 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 887826 的部分引用包括：

Cho et al (2013) Injury-induced HDAC5 nuclear export is essential for axon regeneration. Nat Chem Biol 155 894 PMID: 24209626

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