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A 971432

Cat. No. 5766 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective S1P5 agonist
化学名： 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 971432

A 971432 is a potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

技术数据 for A 971432

分子量 366.24
公式 C18H17Cl2NO3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1240308-45-5
PubChem ID 46872626
InChI Key WAAWETUDFSIYSD-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C=C(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 971432

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 36.62 100
1eq. HCl 36.62 100

制备储备液 for A 971432

以下数据基于产品分子量 366.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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参考文献 for A 971432

参考文献是支持产品生物活性的出版物。

Hobson et al (2015) Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 58 9154 PMID: 26509640

If you know of a relevant reference for A 971432, please let us know.

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关键词: A 971432, A 971432 supplier, A971432, potent, selective, S1P5, sphingosine, phosphate, receptors, neurodegeneration, orally, bioavailable, blood-brain, barrier, Sphingosine-1-phosphate, Receptors, 5766, Tocris Bioscience

1 篇 A 971432 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 971432 的部分引用包括：

Matsushima-Nishiwaki et al (2018) Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS One 13 e0209050 PMID: 30543684

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