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Submit Reviewα-Conotoxin ImI
Discontinued Product
3119 has been discontinued.
说明： α7 and α9 selective nAChR antagonist
生物活性 for α-Conotoxin ImI
Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.
许可信息
Sold under license from University of Utah
技术数据 for α-Conotoxin ImI
| 分子量 | 1351.6 |
| 公式 | C52H78N20O15S4 |
| 序列 |
GCCSDPRCAWRC (Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12) |
| 储存 | Store at -20°C |
| CAS Number | 156467-85-5 |
| PubChem ID | 76324742 |
| InChI Key | AIKMSOHWSGWCNX-VAYQAVKTSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CNC4=C3C=CC=C4)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for α-Conotoxin ImI
参考文献 for α-Conotoxin ImI
参考文献是支持产品生物活性的出版物。
McIntosh et al (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI. J.Biol.Chem. 269 16733 PMID: 8206995
Johnson et al (1995) α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors. Mol.Pharmacol. 48 194 PMID: 7651351
Pereira et al (1996) α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. J.Pharmacol.Exp.Ther. 278 1472 PMID: 8819535
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关键词: alpha-conotoxin ImI, alpha-conotoxin ImI supplier, α7, alpha7, a7, α9, alpha9, a9, selective, nAChR, antagonists, Nicotinic, Receptors, Acetylcholine, Non-Selective, α-conotoxin, alpha-conotoxin, ImI, a-conotoxinImI, conotoxins, venoms, (a7), (Other, Subtypes), 3119, Tocris Bioscience
1 篇 α-Conotoxin ImI 的引用文献
引用文献是使用了 Tocris 产品的出版物。 α-Conotoxin ImI 的部分引用包括：
White et al (2016) Nicotine inhibits potassium currents in Aplysia bag cell neurons. J Neurophysiol 115 2635 PMID: 26864763
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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