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Submit ReviewAAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.
Sold under license from Photoswitch Biosciences, Inc.
分子量 | 443.97 |
公式 | C23H30ClN5O2 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
PubChem ID | 91826090 |
InChI Key | CTVKLIGDHHKPIB-UHFFFAOYSA-N |
Smiles | O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 8.88 | 20 |
以下数据基于产品分子量 443.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 11.26 mL | 56.31 mL | 112.62 mL |
1 mM | 2.25 mL | 11.26 mL | 22.52 mL |
2 mM | 1.13 mL | 5.63 mL | 11.26 mL |
10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
参考文献是支持产品生物活性的出版物。
Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID: 18311146
Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271 PMID: 22841312
Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609
If you know of a relevant reference for AAQ chloride, please let us know.
关键词: AAQ chloride, AAQ chloride supplier, selective, photoswitchable, Kv, potassium, channels, K+, blockers, ligands, Photoswitchable, Ligands, Voltage-Gated, Potassium, Channels, 5462, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 AAQ chloride 的部分引用包括:
Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur J Pharmacol. 938 175448 PMID: 36470444
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