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AAQ chloride

Cat. No. 5462 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Photoswitchable Kv channel blocker
化学名： N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AAQ chloride

AAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.

许可信息

Sold under license from Photoswitch Biosciences, Inc.

技术数据 for AAQ chloride

分子量 443.97
公式 C23H30ClN5O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 91826090
InChI Key CTVKLIGDHHKPIB-UHFFFAOYSA-N
Smiles O=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AAQ chloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.88 20

制备储备液 for AAQ chloride

以下数据基于产品分子量 443.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.26 mL 56.31 mL 112.62 mL
1 mM 2.25 mL 11.26 mL 22.52 mL
2 mM 1.13 mL 5.63 mL 11.26 mL
10 mM 0.23 mL 1.13 mL 2.25 mL

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参考文献 for AAQ chloride

参考文献是支持产品生物活性的出版物。

Fortin et al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331 PMID: 18311146

Polosukhina et al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271 PMID: 22841312

Banghart et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609

If you know of a relevant reference for AAQ chloride, please let us know.

按标靶查看相关产品

关键词: AAQ chloride, AAQ chloride supplier, selective, photoswitchable, Kv, potassium, channels, K+, blockers, ligands, Photoswitchable, Ligands, Voltage-Gated, Potassium, Channels, 5462, Tocris Bioscience

1 篇 AAQ chloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AAQ chloride 的部分引用包括：

Nikolaev et al (2022) Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors. Eur J Pharmacol. 938 175448 PMID: 36470444

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