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Submit ReviewAbacavir hemisulfate
说明： Reverse transcriptase inhibitor; antiretroviral
化学名： (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
纯度： ≥99% (HPLC)
生物活性 for Abacavir hemisulfate
Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.
许可信息
Sold for research purposes under agreement from Viiv.
化合物库 for Abacavir hemisulfate
Abacavir hemisulfate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Abacavir hemisulfate
| 分子量 | 335.37 |
| 公式 | C14H18N6O.½H2SO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 188062-50-2 |
| PubChem ID | 75539558 |
| InChI Key | WMHSRBZIJNQHKT-NHMRBCHTSA-N |
| Smiles | OS(O)(=O)=O.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1.NC1=NC(NC2CC2)=C2N=CN(C3C[C@H](CO)C=C3)C2=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Abacavir hemisulfate
参考文献 for Abacavir hemisulfate
参考文献是支持产品生物活性的出版物。
Charneira et al (2012) N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 167 1353 PMID: 22725138
Harrigan et al (2000) Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 181 912 PMID: 10720512
Daluge et al (1997) 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 41 1082 PMID: 9145874
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1 篇 Abacavir hemisulfate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Abacavir hemisulfate 的部分引用包括：
Roshanak et al (2019) Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife 8 PMID: 31433293
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.