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Submit ReviewABS 205
说明： Upregulates NCAM expression. Valproic acid (Cat. No. 2815) derivative
别名： 4-yn-VPA
化学名： 2-Propyl-4-pentynoic acid
生物活性 for ABS 205
Orally active valproic acid (Cat No. 2815) derivative that exhibits teratogenic and neuroprotective activity. Upregulates neural cell adhesion molecule (NCAM) expression, activates PPARδ (IC50 = 0.6 mM) and increases Hoxa1 expression in rat embryos. Antiproliferative; induces G1 cell cycle arrest in C6 glioma cells (IC50 ~ 2 mM).
技术数据 for ABS 205
| 分子量 | 140.18 |
| 公式 | C8H12O2 |
| 储存 | Store at +4°C |
| CAS Number | 24102-11-2 |
| Smiles | CCCC(C(O)=O)CC#C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ABS 205
参考文献 for ABS 205
参考文献是支持产品生物活性的出版物。
Bacon et al (1998) Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: application to valproic acid and related analogues of varying potency. Toxicol.In Vitro 12 101 PMID: 20654391
Lampen et al (2005) Modulation of peroxisome proliferator-activated receptor δ activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol.Pharmacol. 68 193 PMID: 15829700
Stodgell et al (2006) Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action. Neurotoxicol.Teratol. 28 617 PMID: 16989981
关键词: ABS 205, ABS 205 supplier, Upregulates, NCAM, expression, Adhesion, Molecules, ABS205, 4-yn-VPA, Cell, 2721, Tocris Bioscience
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