主页 / 药理学 / Ion Channels / Calcium Channels / Voltage-gated Calcium Channels (CaV) / CaV3.x Channels (T-type) / CaV3.x Channel (T-type) Blockers / ABT 639

ABT 639

Cat. No. 6770 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： CaV3.2 and CaV3.1 channel blocker; orally bioavailable
化学名： 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ABT 639

ABT 639 is a CaV3.2 channel blocker (IC50 = 2.3 μM). Also blocks low voltage-activated (CaV3.1) currents in native rat DRG neurons (IC50 = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

化合物库 for ABT 639

ABT 639 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ABT 639

分子量 455.91
公式 C20H20ClF2N3O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1235560-28-7
PubChem ID 46851313
InChI Key AGPIHNZOZNKRGT-CYBMUJFWSA-N
Smiles [H][C@]12CCCN1CCN(C(C3=CC(S(=O)(NC4=C(C=CC=C4)F)=O)=C(C=C3Cl)F)=O)C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ABT 639

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.12 20

制备储备液 for ABT 639

以下数据基于产品分子量 455.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.97 mL 54.84 mL 109.67 mL
1 mM 2.19 mL 10.97 mL 21.93 mL
2 mM 1.1 mL 5.48 mL 10.97 mL
10 mM 0.22 mL 1.1 mL 2.19 mL

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参考文献 for ABT 639

参考文献是支持产品生物活性的出版物。

Zhang et al (2015) Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 6 641 PMID: 26101566

If you know of a relevant reference for ABT 639, please let us know.

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关键词: ABT 639, ABT 639 supplier, ABT639, T-type, calcium, channel, blockers, blocks, CaV3.2, CaV3.1, antinociceptive, orally, bioavailable, Cav3.x, Channels, 6770, Tocris Bioscience

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