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AC 261066

Cat. No. 4046 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： RARβ2 agonist
化学名： 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AC 261066

AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).

化合物库 for AC 261066

AC 261066 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AC 261066

分子量 353.41
公式 C17H20FNO4S
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 870773-76-5
PubChem ID 11530459
InChI Key HSAOETBFVAWNRP-UHFFFAOYSA-N
Smiles CC1=C(OCCOCCCC)N=C(C2=CC=C(C(O)=O)C(F)=C2)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 261066

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.34 100
ethanol 35.34 100

制备储备液 for AC 261066

以下数据基于产品分子量 353.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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参考文献 for AC 261066

参考文献是支持产品生物活性的出版物。

Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517 PMID: 16302793

Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem. 52 1540 PMID: 19239230

If you know of a relevant reference for AC 261066, please let us know.

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关键词: AC 261066, AC 261066 supplier, AC261066, RAR, retinoic, acid, receptor, agonists, beta, b, β, agonist, Retinoic, Acid, Receptors, 4046, Tocris Bioscience

1 篇 AC 261066 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AC 261066 的部分引用包括：

Lorraine J et al (2022) A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. Biofactors 48 469-480 PMID: 34687254

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.