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AC 264613

Cat. No. 3370 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PAR2 receptor agonist
化学名： (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AC 264613

AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca2+ mobilization and cellular proliferation in vitro (pEC50 values are 6.9, 7.0 and 7.5 respectively).

化合物库 for AC 264613

AC 264613 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AC 264613

分子量 400.27
公式 C19H18BrN3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1051487-82-1
PubChem ID 25108278
InChI Key RQKXQCSEZPQBNZ-QSBCOWLBSA-N
Smiles O=C1[C@@H]([C@](N/N=C(C)/C3=CC=CC(Br)=C3)=O)[C@H]([C@]2=CC=CC=C2)CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 264613

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.03 100

制备储备液 for AC 264613

以下数据基于产品分子量 400.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.98 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for AC 264613

参考文献是支持产品生物活性的出版物。

Gardell et al (2008) Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 327 799 PMID: 18768780

Seitzberg et al (2008) Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 51 5490 PMID: 18720984

If you know of a relevant reference for AC 264613, please let us know.

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关键词: AC 264613, AC 264613 supplier, Potent, selective, PAR2, agonists, receptors, protease-activated, proteinase-activated, AC264613, Protease-Activated, Receptors, 3370, Tocris Bioscience

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