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Submit ReviewAC 265347
说明： Biased allosteric modulator of calcium-sensing receptor (CaSR)
化学名： α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
纯度： ≥99% (HPLC)
生物活性 for AC 265347
AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.
化合物库 for AC 265347
AC 265347 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AC 265347
| 分子量 | 283.39 |
| 公式 | C17H17NOS |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1253901-26-6 |
| PubChem ID | 52943938 |
| InChI Key | IGSZVEPQZANNAB-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=C(C(O)(C2=NC3=CC=CC=C3S2)C)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AC 265347
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.34 | 100 | |
| ethanol | 28.34 | 100 |
制备储备液 for AC 265347
以下数据基于产品分子量 283.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.64 mL | 35.29 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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产品说明书 for AC 265347
参考文献 for AC 265347
参考文献是支持产品生物活性的出版物。
Cook et al (2015) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. Br.J.Pharmacol. 172 185 PMID: 25220431
Ma et al (2011) Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 337 275 PMID: 21239511
Leach et al (2016) Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell.Res. 26 574 PMID: 27002221
If you know of a relevant reference for AC 265347, please let us know.
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关键词: AC 265347, AC 265347 supplier, AC265347, CaSR, biased, allosteric, modulator, calcimimetic, parathyroid, homrone, PTH, calcitonin, PERK1/2, IP1, accumulation, orally, active, Calcium-Sensing, Receptor, 6165, Tocris Bioscience
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