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说明： Photoswitchable TRPV1 channel blocker
化学名： 1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamide
纯度： ≥98% (HPLC)
生物活性 for AC 4
AC 4 is a photoswitchable TRPV1 channel blocker (IC50 = 3.1 μM). Acts as an antagonist in trans conformation during voltage gated activation. Also acts as an antagonist in the cis formation during capsaicin-induced TRPV1 currents. Switches conformation from cis to trans at 440 nm and trans to cis at 360 nm. Allows photoswitchable antagonist and an agonist to be applied at the same time.
技术数据 for AC 4
| 分子量 | 514.56 |
| 公式 | C26H25F3N4O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1459809-09-6 |
| PubChem ID | 121513863 |
| InChI Key | COPZFJSJZPCWFD-UHFFFAOYSA-N |
| Smiles | S=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AC 4
参考文献 for AC 4
参考文献是支持产品生物活性的出版物。
Stein et al (2013) Optical control of TRPV1 channels. Angew.Chem.Int.Ed.Engl. 52 9845 PMID: 23873837
关键词: AC 4, AC 4 supplier, Photoswitchable, TRPV1, channel, blockers, transient, receptor, potential, vanilloids, ligands, Ligands, TRPV, 5464, Tocris Bioscience
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