AC 710

Cat. No. 5013 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective PDGFR family inhibitor

化学名： N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AC 710

AC 710 is a potent PDGFR family inhibitor (IC₅₀ values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; K_d = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

化合物库 for AC 710

AC 710 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AC 710

分子量	562.7
公式	C₃₁H₄₂N₆O₄
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1351522-04-7
PubChem ID	54760053
InChI Key	JVCWPUFNLFSKFS-UHFFFAOYSA-N
Smiles	CC(C2)(C)N(CC)C(C)(C)CC2OC1=CC=C(C(NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=O)N=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 710

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	11.25	20

制备储备液 for AC 710

以下数据基于产品分子量 562.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	8.89 mL	44.43 mL	88.86 mL
1 mM	1.78 mL	8.89 mL	17.77 mL
2 mM	0.89 mL	4.44 mL	8.89 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

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产品说明书 for AC 710

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AC 710

参考文献是支持产品生物活性的出版物。

Liu et al (2012) Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 3 997 PMID: 24900421

If you know of a relevant reference for AC 710, please let us know.

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关键词: AC 710, AC 710 supplier, AC710, potent, PDGFR, platelet, derived, growth, factor, receptors, family, inhibitors, inhibits, KIT, FLT3, PDGFRalpha, PDGFRa, PDGFRα, PDGFRbeta, PDGFRb, PDGFRβ, CSFR1, antitumor, arthritis, FMS-like, tyrosine, kinases, c-fms, M-CSFR, Other, RTKs, 5013, Tocris Bioscience

1 篇 AC 710 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AC 710 的部分引用包括：

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051

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