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Submit ReviewAc-FLTD-CMK
说明： Potent and selective inhibitor of caspases 1, 5 and 4
纯度： ≥95% (HPLC)
生物活性 for Ac-FLTD-CMK
Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.
技术数据 for Ac-FLTD-CMK
| 分子量 | 569.05 |
| 公式 | C26H37ClN4O8 |
| 序列 |
FLTD (Modifications: Phe-1 = Ac-Phe, Asp-4 = Asp-CMK) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2376255-48-8 |
| PubChem ID | 155906572 |
| InChI Key | UCWNTWGHVCSMJP-WPUDHWPRSA-N |
| Smiles | O=C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ac-FLTD-CMK
| 溶解性 | Soluble to 1 mg/ml in DMSO |
产品说明书 for Ac-FLTD-CMK
参考文献 for Ac-FLTD-CMK
参考文献是支持产品生物活性的出版物。
Yang et al (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc.Natl.Acad.Sci.U.S.A. 115 6792 PMID: 29891674
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关键词: Ac-FLTD-CMK, Ac-FLTD-CMK supplier, AcFLTDCMK, potent, selective, inhibitors, inhibits, caspases, inflammasome, pyroptosis, IL-b, IL-beta, caspase1, Caspases, 7242, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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