[Ac-Tyr¹,D-Phe²]GRF 1-29, amide (human)

Name: [Ac-Tyr 1 ,D-Phe 2 ]GRF 1-29, amide (human)
Brand: Tocris Bioscience
SKU: 1172

Cat. No. 1172 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1172 has been discontinued.

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说明： VIP receptor antagonist

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性

VIP receptor antagonist; inhibits [¹²⁵I]iodo-VIP binding and selectively inhibits VIP- and GRF-induced effects on adenylyl cyclase.

技术数据

分子量	3475
公式	C₁₅₇H₂₅₂N₄₄O₄₃S
序列	YFDAIFTNSYRKVLGQLSARKLLQDIMSR (Modifications: Tyr-1 = N-terminal Ac, Phe-2 = D-Phe, Arg-29 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	93965-89-0
PubChem ID	56841984
InChI Key	ZADZHIQNEPVWIV-QSAFYHFUSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(C)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Nowak et al (1994) Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist. Neuropeptides 27 297 PMID: 7862261

Waelbroeck et al (1985) Interaction of GH-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr¹,D-Phe²)-GRF(1-29)-NH₂ as a VIP antagonist. Endocrinology 116 2643 PMID: 2859987

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关键词: [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human), [Ac-Tyr1,D-Phe2]GRF 1-29, amide (human) supplier, VIP, antagonist, Vasoactive, Intestinal, Peptide, Receptors, VPAC, [Ac-Tyr1D-Phe2]GRF1-29, amide, (human), 1172, Tocris Bioscience

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