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Ac2-12

Cat. No. 1846 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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1846 has been discontinued.

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说明： Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Ac2-12

Ac2-12 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.

技术数据 for Ac2-12

分子量 1351.58
公式 C63H94N14O17S
序列 AMVSEFLKQAW

(Modifications: Ala-1 = N-terminal Ac)
储存 Desiccate at -20°C
CAS Number 256447-08-2
PubChem ID 90488718
InChI Key SUDAISORCUBKHK-RCVXMRHOSA-N
Smiles CSCC[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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参考文献 for Ac2-12

参考文献是支持产品生物活性的出版物。

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1 Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (2001) Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am.J.Pathol. 158 1969 PMID: 11395373

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关键词: Ac2-12, Ac2-12 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1846, Tocris Bioscience

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