Ac2-26

Cat. No. 1845 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

纯度： ≥95% (HPLC)

说明书

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ac2-26

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Negative control also available.

技术数据 for Ac2-26

分子量	3089.46
公式	C₁₄₁H₂₁₀N₃₂O₄₄S
序列	AMVSEFLKQAWFIENEEQEYVQTVK (Modifications: Ala-1 = N-terminal Ac)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	151988-33-9
PubChem ID	16138723
InChI Key	ODWGEWZOPBDSHW-ISLQBSBZSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ac2-26

溶解性	Soluble to 1 mg/ml in PBS

产品说明书 for Ac2-26

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ac2-26

参考文献是支持产品生物活性的出版物。

Lim et al (1998) Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc.Natl.Acad.Sci.U.S.A. 95 14535 PMID: 9826735

Perretti et al (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J.Immunol. 151 4306 PMID: 8409403

Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60 PMID: 12644621

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215 PMID: 25664854

Silistino-Souza et al (2007) Annexin 1: differential expression in tumor and mast cells in human larynx cancer Int.J.Cancer 120 2582 PMID: 17340616

Cardin et al (2019) Annexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis. FEBS Open Bio 9 668 PMID: 30984541

If you know of a relevant reference for Ac2-26, please let us know.

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关键词: Ac2-26, Ac2-26 supplier, Annexin, lipocortin, 1-mimetic, inhibits, inhibitors, leukocyte, extravasation, Adhesion, Molecules, Cell, 1845, Tocris Bioscience