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Submit ReviewAcetaminophen
说明： Cyclooxygenase inhibitor; may be selective for COX-3
别名： Paracetamol
化学名： N-(4-Hydroxyphenyl)acetamide
纯度： ≥99% (HPLC)
生物活性 for Acetaminophen
Acetaminophen is a cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
化合物库 for Acetaminophen
Acetaminophen is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Acetaminophen
| 分子量 | 151.16 |
| 公式 | C8H9NO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 103-90-2 |
| PubChem ID | 1983 |
| InChI Key | RZVAJINKPMORJF-UHFFFAOYSA-N |
| Smiles | CC(=O)NC1=CC=C(O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Acetaminophen
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 15.12 | 100 | |
| DMSO | 15.12 | 100 |
制备储备液 for Acetaminophen
以下数据基于产品分子量 151.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.62 mL | 33.08 mL | 66.16 mL |
| 5 mM | 1.32 mL | 6.62 mL | 13.23 mL |
| 10 mM | 0.66 mL | 3.31 mL | 6.62 mL |
| 50 mM | 0.13 mL | 0.66 mL | 1.32 mL |
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产品说明书 for Acetaminophen
参考文献 for Acetaminophen
参考文献是支持产品生物活性的出版物。
Chandrasekharan et al (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 99 13926 PMID: 12242329
Chong et al (2001) Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 35 1476 PMID: 11724102
Riendeau et al (1997) Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 75 1088 PMID: 9365818
If you know of a relevant reference for Acetaminophen, please let us know.
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关键词: Acetaminophen, Acetaminophen supplier, Cyclooxygenase, inhibitors, inhibits, COX-3, Oxygenases, Oxidases, Paracetamol, 1706, Tocris Bioscience
3 篇 Acetaminophen 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Acetaminophen 的部分引用包括：
Inagaki et al (2012) Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. J Neurosci 13 13 PMID: 23137391
Liu and Gao (2007) Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol 97 837 PMID: 17093123
Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A 104 4083 PMID: 17360481
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