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Acifran

Cat. No. 1762 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
别名： AY 25712
化学名： 4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Acifran

Acifran is a hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.

技术数据 for Acifran

分子量 218.21
公式 C12H10O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 72420-38-3
PubChem ID 51576
InChI Key DFDGRKNOFOJBAJ-UHFFFAOYSA-N
Smiles CC1(OC(=CC1=O)C(O)=O)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Acifran

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 21.82 100
DMSO 21.82 100

制备储备液 for Acifran

以下数据基于产品分子量 218.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.58 mL 22.91 mL 45.83 mL
5 mM 0.92 mL 4.58 mL 9.17 mL
10 mM 0.46 mL 2.29 mL 4.58 mL
50 mM 0.09 mL 0.46 mL 0.92 mL

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产品说明书 for Acifran

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Acifran

参考文献是支持产品生物活性的出版物。

Cayen et al (1982) Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 45 267 PMID: 6818976

Jirkovsky and Cayen (1982) Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 25 1154 PMID: 7143351

Jung et al (2007) Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 50 1445 PMID: 17358052

Wise et al (2003) Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 278 9869 PMID: 12522134

If you know of a relevant reference for Acifran, please let us know.

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关键词: Acifran, Acifran supplier, Hypolipidemic, agent, agonists, GPR109A, HM74A, GPR109B, receptors, HM74, nicotinic, acid, AY25712, AY, 25712, Hydroxycarboxylic, Acid, Receptors, 1762, Tocris Bioscience

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