Acridine Orange hydrochloride

Cat. No. 5092 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Nucleic acid binding dye. Cell permeable. Used for: cell cycle and apoptosis determination. Application: flow cytometry, fluorescence microscopy

化学名： N,N,N',N'-Tetramethyl-3,6-acridinediamine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Acridine Orange hydrochloride

Key information: Acridine Orange hydrochloride is a nucleic acid binding dye. Cell and organelle permeable.

Used for: cell cycle and apoptosis determination, for visual detection of nucleic acids on agarose and polyacrylamide gels, for autophagy analyze.

Application: suitable for flow cytometry and fluorescence microscopy.

Properties and Photophysical Data: emits green fluorescence when incorporated into double-stranded DNA, red fluorescence when bound electrostatically to phosphate groups of RNA or single-stranded DNA, and orange fluorescence in acidic conditions. Excitation and emission maxima (λ) are 502 nm and 525 nm, respectively (green, double strands)/ 460 nm and 650 nm, respectively (red, single strands)/ and 475 nm and 590 nm, respectively (orange, acidic conditions).

This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

技术数据 for Acridine Orange hydrochloride

M. Wt	265.36 (Free Base)
公式	C₁₇H₁₉N₃.HCl
储存	Store at RT
纯度	≥98% (HPLC)
PubChem ID	517204
InChI Key	VSTHNGLPHBTRMB-UHFFFAOYSA-N
Smiles	CN(C)C1=CC=C2C(N=C(C=C(N(C)C)C=C3)C3=C2)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Acridine Orange hydrochloride

溶解性	Soluble to 10 mg/ml in water

产品说明书 for Acridine Orange hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Acridine Orange hydrochloride

参考文献是支持产品生物活性的出版物。

Kiyoshima et al (2013) Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. PLoS ONE 8 80998 PMID: 24278362

McMaster et al (1977) Analysis of single and double stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc.Natl.Acad.Sci.USA 74 4835 PMID: 73185

Ratan et al (2008) Rapid communication: oxidative stress induces apoptosis in embryonic cortical neurons. J.Neurobiol. 62 376 PMID: 7903353

Sato et al (2018) Flow cytometric analysis of Xenopus laevis and X. tropicalis blood cells using acridine orange. Sci.Rep. 8 16245 PMID: 30390005

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1 篇 Acridine Orange hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Acridine Orange hydrochloride 的部分引用包括：

Stephan et al (2022) Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol 162 112869 PMID: 35182693

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