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Description: Fluorescent unnatural amino acid.
Chemical Name: Sodium 2-Amino-3-(9-oxo-9,10-dihydroacridin-2-yl)propanoate
Purity: ≥95% (HPLC)
Biological Activity for Acridonylalanine
Key information: Acridonylalanine is a fluorescent unnatural amino acid. Can be used to specifically label a protein of interest during protein translation. Suitable for lifetime and fluorescence resonance energy transfer (FRET) studies.
Used for: labeling proteins, monitoring protein interactions and conformational changes through fluorescence polarization or lifetime experiments.
Application: fluorescence lifetime imaging microscopy (FLIM), FRET interactions with common fluorophores such as methoxycoumarin.
Properties and Photophysical Data: highly photostable, high quantum yield and long fluorescence lifetime in water. Excitation and emission maxima (λ) are 385 nm and 420 nm, respectively.
Optical Data for Acridonylalanine
| λabs | 385 nm |
|---|---|
| λem | 420 nm |
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Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Technical Data for Acridonylalanine
| M. Wt | 304.28 |
| Formula | C16H13N2NaO3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| PubChem ID | 496123694 |
| InChI Key | XZLOZGUCQWEABV-UHFFFAOYSA-M |
| Smiles | O=C1C2=CC(CC(C([O-])=O)N)=CC=C2NC3=CC=CC=C31.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Acridonylalanine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.04 | 10 | |
| water | 3.04 | 10 |
Preparing Stock Solutions for Acridonylalanine
The following data is based on the product molecular weight 304.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.86 mL | 164.32 mL | 328.64 mL |
| 0.5 mM | 6.57 mL | 32.86 mL | 65.73 mL |
| 1 mM | 3.29 mL | 16.43 mL | 32.86 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.57 mL |
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Product Datasheets for Acridonylalanine
References for Acridonylalanine
References are publications that support the biological activity of the product.
Hostetler et al (2018) Systematic evaluation of soluble protein expression using a fluorescent unnatural amino acid reveals no reliable predictors of tolerability. ACS Chem.Biol. 13 2855 PMID: 30216041
Speight et al (2013) Efficient synthesis and in vivo incorporation of acridon-2-ylalanine, a fluorescent amino acid for lifetime and Förster resonance energy transfer/luminescence resonance energy transfer studies. J.Am.Chem.Soc. 135 18806 PMID: 24303933
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