Adenosine 5'-(α,β-methylene)diphosphate disodium salt 最新

Cat. No. 8173 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Ecto-5'-nucleotidase (CD73) inhibitor

化学名： α,β-Methyleneadenosine 5'-diphosphate disodium salt

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor, induces inflammation in a rodent model of pleurisy, and reduces memory loss induced by Aβ_1-42 in a mouse model of Alzheimer's disease.

技术数据

分子量	469.19
公式	C₁₁H₁₅N₅Na₂O₉P₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	104835-70-3
InChI Key	XBMIJZIUIGRFDM-LYYWGVPGSA-L
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(CP(O)(O[Na])=O)(O[Na])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	PBS	4.69	10

制备储备液

以下数据基于产品分子量 469.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	21.31 mL	106.57 mL	213.13 mL
0.5 mM	4.26 mL	21.31 mL	42.63 mL
1 mM	2.13 mL	10.66 mL	21.31 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

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产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Niemelä et al (2008) IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. Eur.J.Immunol. 38 2718 PMID: 18825744

Kur et al (2014) Purinergic control of vascular tone in the retina. J.Physiol. 592 491 PMID: 24277867

Ujházy et al (1996) Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. Int.J.Cancer 68 493 PMID: 8945621

Chen et al (2019) Asthmatic augmentation of airway vagal activity involves decreased central expression and activity of CD73 in rats. ACS Chem.Neurosci. 10 2809 PMID: 30913879

Caiazzo et al (2019) The ecto-5'-nucleotidase/CD73 inhibitor, α,β-methylene adenosine 5'-diphosphate, exacerbates carrageenan-induced pleurisy in rat. Front.Pharmacol. 10 775 PMID: 31354490

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关键词: Adenosine 5'-(a,b-methylene)diphosphate disodium salt, Adenosine 5'-(a,b-methylene)diphosphate disodium salt supplier, meATP, Ecto-5'-nucleotidase/, CD73, inhibitors, inhibits, adenosine, doxorubicin-resistance, vasoconstrictor, NT5E, eN, eNT, 5', nucleotidase, ecto-5'-NT, 5-(a,b-methylene)diphosphate, P2X, inflammation, pleurisy, amyloid, NTPDase, 8173, Tocris Bioscience

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