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Submit ReviewAdipoRon hydrochloride
说明： Orally active AdipoR1 and AdipoR2 agonist; antidiabetic
化学名： 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for AdipoRon hydrochloride
AdipoRon hydrochloride is an agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd values are 1.8 and 3.1 μM respectively). Activates AMPK and PPARα signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db mice. Orally active antidiabetic agent.
化合物库 for AdipoRon hydrochloride
AdipoRon hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AdipoRon hydrochloride
| 分子量 | 464.98 |
| 公式 | C27H28N2O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1781835-20-8 |
| PubChem ID | 78243714 |
| InChI Key | TZVJQEGKRLDTHQ-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=C(OCC(NC3CCN(CC4=CC=CC=C4)CC3)=O)C=C2)C1=CC=CC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AdipoRon hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 46.5 | 100 | |
| ethanol | 4.65 | 10 |
制备储备液 for AdipoRon hydrochloride
以下数据基于产品分子量 464.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.75 mL | 21.51 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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产品说明书 for AdipoRon hydrochloride
参考文献 for AdipoRon hydrochloride
参考文献是支持产品生物活性的出版物。
Okada-Iwabu et al (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503 493 PMID: 24172895
If you know of a relevant reference for AdipoRon hydrochloride, please let us know.
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关键词: AdipoRon hydrochloride, AdipoRon hydrochloride supplier, antidiabetic, adiponectin, receptors, ApoR1, ApoR2, agonists, orally, active, Other, Peptide, Receptors, 5096, Tocris Bioscience
1 篇 AdipoRon hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AdipoRon hydrochloride 的部分引用包括：
Sung et al (2019) Iron induces ins. resistance in cardiomyocytes via regulation of oxidative stress. Sci Rep 9 4668 PMID: 30874600
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AdipoRon hydrochloride 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.