AF 64394

Pricing Availability   Qty
说明: Potent and selective GPR3 inverse agonist
化学名: N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
纯度: ≥98% (HPLC)
说明书
引用文献
评论

生物活性 for AF 64394

AF 64394 is a potent and selective GPR3 inverse agonist (pIC50 = 7.3). Selective for GPR3 over GPR6 and GPR12 (pIC50 values are 5.1 and 4.9, respectively).

化合物库 for AF 64394

AF 64394 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AF 64394

分子量 393.87
公式 C21H20ClN5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1637300-25-4
PubChem ID 125286314
InChI Key WBYNZQXAAWPAGR-UHFFFAOYSA-N
Smiles CC(C)OC1=C(CNC2=CC(=NC3=NC=NN23)C2=CC=CC=C2)C=CC(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AF 64394

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.39 100

制备储备液 for AF 64394

以下数据基于产品分子量 393.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.69 mL 25.39 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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参考文献 for AF 64394

参考文献是支持产品生物活性的出版物。

Jensen et al (2014) The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. Bioorg.Med.Chem.Lett. 24 5195 PMID: 25442311

Godlewski et al (2015) Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue. Sci.Rep. 5 14953 PMID: 26455425


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