AG 490

Cat. No. 0414 14 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

别名： Tyrphostin AG 490

化学名： (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

纯度： ≥99% (HPLC)

引用文献 (14)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AG 490

AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC₅₀ values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.

技术数据 for AG 490

分子量	294.31
公式	C₁₇H₁₄N₂O₃
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	133550-30-8
PubChem ID	5328779
InChI Key	TUCIOBMMDDOEMM-RIYZIHGNSA-N
Smiles	OC1=C(O)C=C(\C=C(/C#N)C(=O)NCC2=CC=CC=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AG 490

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	5.89	20
	DMSO	29.43	100

制备储备液 for AG 490

以下数据基于产品分子量 294.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.4 mL	16.99 mL	33.98 mL
5 mM	0.68 mL	3.4 mL	6.8 mL
10 mM	0.34 mL	1.7 mL	3.4 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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产品说明书 for AG 490

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AG 490

参考文献是支持产品生物活性的出版物。

Abe et al (2009) The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice. Int.Immunopharmacol. 9 870 PMID: 19327411

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896 PMID: 1676428

Meydan et al (1996) Inhbition of acute lymphoblastic leukaemia by a JAK-2 inhibitor. Nature 379 645 PMID: 8628398

Wang et al (1999) JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J.Immunol. 162 3897 PMID: 10201908

If you know of a relevant reference for AG 490, please let us know.

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