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Submit ReviewAH 6809
说明： EP1 and EP2 receptor antagonist
化学名： 6-Isopropoxy-9-xanthone-2-carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for AH 6809
AH 6809 is an antagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).
化合物库 for AH 6809
AH 6809 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AH 6809
| 分子量 | 298.3 |
| 公式 | C17H14O5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 33458-93-4 |
| PubChem ID | 119461 |
| InChI Key | AQFFXPQJLZFABJ-UHFFFAOYSA-N |
| Smiles | CC(C)OC1=CC=C2C(OC3=C(C=C(C=C3)C(O)=O)C2=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AH 6809
参考文献 for AH 6809
参考文献是支持产品生物活性的出版物。
Keery and Lumley (1988) AH 6809, a prostaglandin DP-receptor blocking drug on human platelets. Br.J.Pharmacol. 94 745 PMID: 2460179
Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928
van der Merwe et al (2009) Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. J.Pharmacol.Exp.Ther. 329 747 PMID: 19190238
Coleman et al (1985) AH6809, a prostanoid EP1-receptor blocking drug. Br.J.Pharmacol. 85 273P
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关键词: AH 6809, AH 6809 supplier, EP1, EP2, receptor, antagonists, DP, Receptors, prostanoid, receptors, prostaglandins, prostacyclins, eicosanoids, AH6809, Prostanoid, 0671, Tocris Bioscience
6 篇 AH 6809 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AH 6809 的部分引用包括：
Liu et al (2016) Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice PLoS One 11 e0165200 PMID: 27812120
Passafaro et al (2011) Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland. Br J Pharmacol 8 138 PMID: 22013477
Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10 PMID: 21955547
Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Dent Res J (Isfahan) 19 210 PMID: 25266063
Walsh and Kinsella (2000) Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol 131 601 PMID: 11015313
Schaafsma et al (2007) Ins induces airway smooth muscle contraction. J Pharmacol Exp Ther 150 136 PMID: 17160007
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