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AH 7614

Cat. No. 5256 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective FFA4 (GPR120) antagonist
化学名： 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AH 7614

AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

技术数据 for AH 7614

分子量 351.42
公式 C20H17NO3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 6326-06-3
PubChem ID 233085
InChI Key OZCQEUZTOAAWDK-UHFFFAOYSA-N
Smiles CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AH 7614

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.14 100

制备储备液 for AH 7614

以下数据基于产品分子量 351.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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产品说明书 for AH 7614

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AH 7614

参考文献是支持产品生物活性的出版物。

Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100 PMID: 24881566

If you know of a relevant reference for AH 7614, please let us know.

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关键词: AH 7614, AH 7614 supplier, AH7614, selective, free, fatty, acid, 4, FFA4, receptor, antagonist, GPR120, Free, Fatty, Acid, Receptors, 5256, Tocris Bioscience

2 篇 AH 7614 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AH 7614 的部分引用包括：

Chen et al (2018) Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model. Mol Med 24 60 PMID: 30482157

Kishikawa et al (2019) Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation. Front Endocrinol (Lausanne) 10 157 PMID: 30949128

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