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Submit ReviewGSK 137647
Description: Potent and selective FFA4 (GPR120) agonist
Chemical Name: 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Biological Activity for GSK 137647
GSK 137647 is a potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614 (Cat. No. 5256).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Compound Libraries for GSK 137647
GSK 137647 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for GSK 137647
| M. Wt | 305.39 |
| Formula | C16H19NO3S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 349085-82-1 |
| PubChem ID | 743974 |
| InChI Key | FQUAFMNPXPXOJE-UHFFFAOYSA-N |
| Smiles | CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GSK 137647
References for GSK 137647
References are publications that support the biological activity of the product.
Sparks et al (2014) Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg.Med.Chem.Lett. 24 3100 PMID: 24881566
Martin et al (2012) Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. J.Lipid Res. 53 2256 PMID: 22904345
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Keywords: GSK 137647, GSK 137647 supplier, GSK137647, Free, fatty, acid, receptor, 4, diabetes, potent, and, selective, FFA4, GPR120, agonist, Fatty, Acid, Receptors, 5257, Tocris Bioscience
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