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说明： ARE activator; induces Nrf2-ARE-dependent transcription
化学名： 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
纯度： ≥98% (HPLC)
生物活性 for AI-3
AI-3 is an antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.
技术数据 for AI-3
| 分子量 | 292.8 |
| 公式 | C11H13ClO3S2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 882288-28-0 |
| PubChem ID | 2820824 |
| InChI Key | PVJWSALSWFDIMS-UHFFFAOYSA-N |
| Smiles | O=C1CC(C)(C)CC2=C(Cl)SC(S(=O)(C)=O)=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AI-3
参考文献 for AI-3
参考文献是支持产品生物活性的出版物。
Wang et al (2013) In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem.Biol. 8 1764 PMID: 23773140
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关键词: AI-3, AI-3 supplier, antioxidant, response, element, ARE, NRF2, Nuclear, factor, (erythroid-derived-2)-like, 2, activators, induces, cytoprotective, gene, expression, keap1, Nrf2, 5145, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.