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Submit Reviewα-Mangostin
说明： Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
化学名： 1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
纯度： ≥98% (HPLC)
生物活性 for α-Mangostin
α-Mangostin is a xanthone derivative. Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines. Also suppresses the invasive and metastatic ability of pancreatic CSCs by modulation of cadherin expression and suppressing the transcription factors Snail and Slug. Attenuates the expression of Nanog and pluripotency promoting transcription factors, and inhibits Nanog binding. Downregulates the PI 3-K/Akt pathway. Inhibits self-renewal of CSCs isolated from human primary tumors and KrasG12D mice. Inhibits MRSA and VRE. Antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic, anti-inflammatory, antioxidant and neuroprotective.
技术数据 for α-Mangostin
| 分子量 | 410.47 |
| 公式 | C24H26O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 6147-11-1 |
| PubChem ID | 5281650 |
| InChI Key | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
| Smiles | COC1=C(CC=C(C)C)C2=C(OC3=CC(O)=C(CC=C(C)C)C(O)=C3C2=O)C=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for α-Mangostin
参考文献 for α-Mangostin
参考文献是支持产品生物活性的出版物。
Ma et al (2019) Inhibition of pancreatic cancer stem cell characteristics by a-Mangostin: Molecular mechanisms involving Sonic hedgehog and Nanog. J.Cell Mol.Med. 23 2719 PMID: 30712329
Wang et al (2017) Pharmacology of mangostins and their derivatives: A comprehensive review. Chin.J.Nat.Med. 15 81 PMID: 28284429
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关键词: alpha-Mangostin, alpha-Mangostin supplier, alpha-Mangostin, a-Mangostin, Inhibits, proliferation, induces, apoptosis, pancreatic, CSCs, anticarcinogenic, cadherin, expression, modulator, Nanog, pluripotency, promoting, factors, MRSA, VRE, neuroprotective, PI3K, Akt, pathway, antimalarial, antioxidant, can, Cancer, Stem, Cells, Cell, Adhesion, Molecules, Antibiotics, PI, 3-Kinase, Antimalarials, Antioxidants, 6856, Tocris Bioscience
α-Mangostin 的评论
平均评分: 5 (Based on 1 Review.)
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Anti-diabetic study employing alpha -Mangostin.
By
Joe Ques on 04/26/2024
分析类型： In Vitro
种属： Human
Studied the anti-diabetic effects of alpha mangostin. The product performed well under study conditions and produced reproducible results.
alpha -mangostin at a concentration between 100-300 µg/ml used to understand insulin secretion change
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics in Cancer Research Product Guide
This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:
- Histone Methylation
- Histone Acetylation
- DNA Methylation
- Ubiquitination
- Bromodomains
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.