Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAlsterpaullone
Discontinued Product
6400 has been discontinued.
View all CDK1 Subfamily (CDK1, CDK2 & CDK3) products.
说明： Potent CDK1 and CDK2 inhibitor; also inhibits GSK-3β and Lck
化学名： 7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one
纯度： ≥98% (HPLC)
生物活性 for Alsterpaullone
Alsterpaullone is a potent CDK1 and 2 inhibitor (IC50 values are 0.035 and 0.08 μM, respectively). Also inhibits GSK-3β and Lck (IC50 values are 0.11 and 0.47 μM, respectively). Induces apoptosis by activation of caspase-9; inhibits growth of cancer cell lines in vitro. Also glucocorticoid receptor inhibitor.
技术数据 for Alsterpaullone
| 分子量 | 293.28 |
| 公式 | C16H11N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 237430-03-4 |
| PubChem ID | 5005498 |
| InChI Key | OLUKILHGKRVDCT-UHFFFAOYSA-N |
| Smiles | O=C1CC2=C(C3=CC=CC=C3N1)NC4=C2C=C([N+]([O-])=O)C=C4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Alsterpaullone
参考文献 for Alsterpaullone
参考文献是支持产品生物活性的出版物。
Schulz et al (1999) Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J.Med.Chem. 42 2909 PMID: 10425100
Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199 PMID: 12534346
Lahusen et al (2003) Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol.Carcinog. 36 183 PMID: 12669310
Jiang et al (2017) A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor. Sci.Rep. 7 6405 PMID: 28785063
按标靶查看相关产品
按产品操作查看相关产品
关键词: Alsterpaullone, Alsterpaullone supplier, cdk1, cdk2, cyclin, dependent, kinase, inhibitors, inhibits, glycogen, synthase, GSK-3beta, 3B, β, lck, potent, glucocorticoid, receptor, Glycogen, Synthase, Kinase, 3, Src, Kinases, Glucocorticoid, Receptor, CDK1, Subfamily, 6400, Tocris Bioscience
Alsterpaullone 的评论
目前没有该产品的评论。 Be the first to review Alsterpaullone and earn rewards!
Have you used Alsterpaullone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image