Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAM 4113
说明： High affinity and selective CB1 antagonist
化学名： 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
纯度： ≥98% (HPLC)
生物活性 for AM 4113
AM 4113 is a high affinity and selective CB1 antagonist (Kd = 0.89 nM). Exhibits 100-fold selectivity for CB1 over CB2. Attenuates CB1 agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.
化合物库 for AM 4113
AM 4113 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AM 4113
| 分子量 | 380.66 |
| 公式 | C17H12Cl3N3O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 614726-85-1 |
| PubChem ID | 66844170 |
| InChI Key | BBUKVPCUOHFAQN-UHFFFAOYSA-N |
| Smiles | CC1=C(C2=CC=C(C=C2)Cl)N(C3=C(C=C(C=C3)Cl)Cl)N=C1C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AM 4113
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 7.61 | 20 | |
| ethanol | 7.61 | 20 |
制备储备液 for AM 4113
以下数据基于产品分子量 380.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.14 mL | 65.68 mL | 131.35 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.27 mL |
| 2 mM | 1.31 mL | 6.57 mL | 13.14 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for AM 4113
参考文献 for AM 4113
参考文献是支持产品生物活性的出版物。
Sink et al (2008) The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 33 946 PMID: 17581535
Hodge et al (2008) The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats Behav. Brain Res. 193 298 PMID: 18602425
If you know of a relevant reference for AM 4113, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: AM 4113, AM 4113 supplier, AM4113, high, affinity, selective, CB1, antagonists, Cannabinoids, Receptors, cb1r, 6193, Tocris Bioscience
AM 4113 的评论
目前没有该产品的评论。 Be the first to review AM 4113 and earn rewards!
Have you used AM 4113?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.