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Submit ReviewAM 6545
说明： High affinity and selective CB1 antagonist
化学名： 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
纯度： ≥98% (HPLC)
生物活性 for AM 6545
AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.
化合物库 for AM 6545
AM 6545 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AM 6545
| 分子量 | 556.46 |
| 公式 | C26H23Cl2N5O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1245626-05-4 |
| PubChem ID | 46912919 |
| InChI Key | XBHQLFVDGLPBCK-UHFFFAOYSA-N |
| Smiles | O=C(NN3CCS(CC3)(=O)=O)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(C#CCCC#N)C=C4)=C1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AM 6545
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 11.13 | 20 |
制备储备液 for AM 6545
以下数据基于产品分子量 556.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.99 mL | 44.93 mL | 89.85 mL |
| 1 mM | 1.8 mL | 8.99 mL | 17.97 mL |
| 2 mM | 0.9 mL | 4.49 mL | 8.99 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
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产品说明书 for AM 6545
参考文献 for AM 6545
参考文献是支持产品生物活性的出版物。
Tam et al (2010) Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J.Clin.Invest. 120 2953 PMID: 20664173
Bowles et al (2015) A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc.Natl.Acad.Sci.U.S.A. 112 285 PMID: 25535367
If you know of a relevant reference for AM 6545, please let us know.
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关键词: AM 6545, AM 6545 supplier, AM6545, CB1, receptors, antagonists, high, affinity, selective, obesity, lipids, glucose, Receptors, 5443, Tocris Bioscience
1 篇 AM 6545 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AM 6545 的部分引用包括：
Giulio G et al (2022) Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis. Mol Psychiatry 27 2340-2354 PMID: 35075269
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