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Submit ReviewAMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.
分子量 | 386.84 |
公式 | C19H18N4O3.HCl |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 2095432-75-8 |
PubChem ID | 122705993 |
InChI Key | XZOFNDFDGVAIEH-UHFFFAOYSA-N |
Smiles | COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 38.68 | 100 |
以下数据基于产品分子量 386.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.59 mL | 12.93 mL | 25.85 mL |
5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
参考文献是支持产品生物活性的出版物。
Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987 PMID: 15724259
Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61 PMID: 26613980
Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9 PMID: 27207629
Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266 PMID: 23405280
If you know of a relevant reference for AMBMP hydrochloride, please let us know.
关键词: AMBMP hydrochloride, AMBMP hydrochloride supplier, BML284, CID11210285, wnt, canonical, signaling, pathway, activators, activates, tublulin, polymerization, inhibitors, inhibits, BML, 284, CID, 11210285, Other, Wnt, Signaling, Microtubules, 6043, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 AMBMP hydrochloride 的部分引用包括:
Vadivel et al (2020) SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. Biochem J 477 1409-1425 PMID: 32219372
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