AMBMP hydrochloride

Pricing Availability   Qty
说明: Wnt canonical signaling activator; also tubulin polymerization inhibitor
别名: BML 284,CID 11210285
化学名: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
通路 (1)

生物活性 for AMBMP hydrochloride

AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.

技术数据 for AMBMP hydrochloride

分子量 386.84
公式 C19H18N4O3.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2095432-75-8
PubChem ID 122705993
InChI Key XZOFNDFDGVAIEH-UHFFFAOYSA-N
Smiles COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMBMP hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.68 100

制备储备液 for AMBMP hydrochloride

以下数据基于产品分子量 386.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.93 mL 25.85 mL
5 mM 0.52 mL 2.59 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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产品说明书 for AMBMP hydrochloride

参考文献 for AMBMP hydrochloride

参考文献是支持产品生物活性的出版物。

Liu et al (2005) A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl. 44 1987 PMID: 15724259

Wang et al (2016) 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res. 65 61 PMID: 26613980

Fukuda et al (2016) Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem. 17 9 PMID: 27207629

Denicol et al (2013) Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep. 3 1266 PMID: 23405280


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关键词: AMBMP hydrochloride, AMBMP hydrochloride supplier, BML284, CID11210285, wnt, canonical, signaling, pathway, activators, activates, tublulin, polymerization, inhibitors, inhibits, BML, 284, CID, 11210285, Other, Wnt, Signaling, Microtubules, 6043, Tocris Bioscience

1 篇 AMBMP hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AMBMP hydrochloride 的部分引用包括:

Vadivel et al (2020) SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling. Biochem J 477 1409-1425 PMID: 32219372


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Pathways for AMBMP hydrochloride

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.