Ambroxol hydrochloride

Name: Ambroxol hydrochloride
Brand: Tocris Bioscience
SKU: 2404

Cat. No. 2404 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2404 has been discontinued.

View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.

说明： Na⁺ channel blocker

化学名： trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Ambroxol hydrochloride

Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC₅₀ values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus.

化合物库 for Ambroxol hydrochloride

Ambroxol hydrochloride is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Ambroxol hydrochloride

分子量	414.57
公式	C₁₃H₁₈Br₂N₂O.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	23828-92-4
PubChem ID	108013
InChI Key	QNVKOSLOVOTXKF-UHFFFAOYSA-N
Smiles	NC1=C(Br)C=C(Br)C=C1CN[C@H]2CC[C@H](O)CC2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ambroxol hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ambroxol hydrochloride

参考文献是支持产品生物活性的出版物。

Gillissen et al (1997) Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 175 235 PMID: 9195551

Gibbs et al (1999) Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 48 86 PMID: 10202994

Weiser and Wilson (2002) Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na⁺ channels by the secretolytic ambroxol. Mol.Pharmacol. 62 433 PMID: 12181417

Yang et al (2002) Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur.Respir.J. 19 952 PMID: 12030738

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关键词: Ambroxol hydrochloride, Ambroxol hydrochloride supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, Influenza, Viruses, 2404, Tocris Bioscience

篇 Ambroxol hydrochloride 的引用文献

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目前没有 Ambroxol hydrochloride 的引用文献。