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AMG 517

Cat. No. 5995 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent TRPV1 antagonist
化学名： N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AMG 517

AMG 517 is a potent TRPV1 antagonist (IC50 = 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable.

化合物库 for AMG 517

AMG 517 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AMG 517

分子量 430.41
公式 C20H13F3N4O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 659730-32-2
PubChem ID 16007367
InChI Key YUTIXVXZQIQWGY-UHFFFAOYSA-N
Smiles O=C(NC(S1)=NC(C1=CC=C2)=C2OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG 517

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.3 10

制备储备液 for AMG 517

以下数据基于产品分子量 430.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 23.23 mL 116.17 mL 232.34 mL
0.5 mM 4.65 mL 23.23 mL 46.47 mL
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL

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产品说明书 for AMG 517

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for AMG 517

参考文献是支持产品生物活性的出版物。

Gavva et al (2007) Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J.Pharmacol.Exp.Ther. 323 128 PMID: 17652633

Wang et al (2007) Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J.Med.Chem. 50 3528 PMID: 17585751

Doherty et al (2007) Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J.Med.Chem. 50 3515 PMID: 17585750

If you know of a relevant reference for AMG 517, please let us know.

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关键词: AMG 517, AMG 517 supplier, AMG517, potent, TRPV1, transient, potential, channels, antagonists, pain, antihyperalgesia, TRPV, 5995, Tocris Bioscience

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AMG 517 的评论

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AMG517 blocks TRPV1 function.
By Anonymous on 01/10/2018
分析类型： In Vivo
种属： Mouse

AMG517 was used to relieve SADBE-induced chronic itch in mice via inhibition of TRPV1 function.

AMG517 should be used at the dose of 30mg/kg in in vivo experiments

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