AMG 837 hemicalcium salt

Cat. No. 6082 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent FFA1 (GPR40) partial agonist

化学名： (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AMG 837 hemicalcium salt

AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC₅₀ values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.

化合物库 for AMG 837 hemicalcium salt

AMG 837 hemicalcium salt is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AMG 837 hemicalcium salt

分子量	457.47
公式	C₂₆H₂₀F₃O₃.½Ca
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1291087-14-3
PubChem ID	46854655
InChI Key	WCZAHGONZBHQSA-UHFFFAOYSA-L
Smiles	CC#C[C@H](C1=CC=C(C=C1)OCC2=CC=CC(C3=CC=C(C(F)(F)F)C=C3)=C2)CC([O-])=O.CC#C[C@H](C4=CC=C(C=C4)OCC5=CC=CC(C6=CC=C(C(F)(F)F)C=C6)=C5)CC([O-])=O.[Ca+2]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMG 837 hemicalcium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	45.75	100

制备储备液 for AMG 837 hemicalcium salt

以下数据基于产品分子量 457.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.93 mL	21.86 mL
5 mM	0.44 mL	2.19 mL	4.37 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for AMG 837 hemicalcium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AMG 837 hemicalcium salt

参考文献是支持产品生物活性的出版物。

Houze et al (2012) AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg.Med.Chem.Lett. 22 1267 PMID: 22217876

Lin et al (2012) Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol.Pharmacol. 82 843 PMID: 22859723

Lin et al (2011) AMG 837: a novel GPR40/FFA1 agonist that enhances Ins secretion and lowers glucose levels in rodents. PLoS One 6 e27270 PMID: 22087278

If you know of a relevant reference for AMG 837 hemicalcium salt, please let us know.

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