主页 / 药理学 / Ion Channels / Potassium Channels / Inward Rectifier Potassium (Kir) Channels / Inward Rectifier Potassium (Kir) Channel Blockers / AMP PNP

AMP PNP

Cat. No. 6086 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Kir6 blocker; non-hydrolyzable AMP analog
化学名： Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
纯度： ≥90% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AMP PNP

AMP PNP is a non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

技术数据 for AMP PNP

分子量 529.93
公式 C10H13Li4N6O12P3
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 72957-42-7
PubChem ID 44134521
InChI Key FDBDJIGGLGUOPP-UHFFFAOYSA-J
Smiles NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AMP PNP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 26.5 50

制备储备液 for AMP PNP

以下数据基于产品分子量 529.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 3.77 mL 18.87 mL 37.74 mL
2.5 mM 0.75 mL 3.77 mL 7.55 mL
5 mM 0.38 mL 1.89 mL 3.77 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for AMP PNP

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for AMP PNP

参考文献是支持产品生物活性的出版物。

Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID: 2412134

Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID: 4326768

Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 23 231 PMID: 7805625

If you know of a relevant reference for AMP PNP, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Inward Rectifier Potassium (Kir) Channel Blockers

关键词: AMP PNP, AMP PNP supplier, AMPPNP, non-hydrolyzable, non-hydrolysable, AMP, analog, adenylyl-imidodiphosphate, tetralithium, salt, Kir6, channel, blockers, blocks, KATP, inward, rectifier, potassium, current, Inward, Potassium, Channels, 6086, Tocris Bioscience

2 篇 AMP PNP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AMP PNP 的部分引用包括：

Shimizu et al (2021) Regulation of TRPV1 channel activities by intracellular ATP in the absence of capsaicin. Biochim.Biophys.Acta Biomembr. 1864 183782 PMID: 34555418

Roland et al (2021) Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle. Sci Adv 7 eabk2392 PMID: 34936443

您是否知道使用了 Tocris AMP PNP 的优秀论文？ 请告知我们.

AMP PNP 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used AMP PNP?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


AMP PNP was used to estimate Kir blocking on Natural Killer cells..
By Anonymous on 01/16/2019
分析类型： In Vitro
种属： Human
细胞系/组织： NK cells

AMP PNP was used to estimate Kir blocking on Natural Killer cells at increasing concentrations.

review image