Anandamide (in Tocrisolve™ 100)

Name: Anandamide (in Tocrisolve™ 100)
Brand: Tocris Bioscience
SKU: 1017

Cat. No. 1017 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1017 has been discontinued.

View all Non-selective Cannabinoids products.

说明： Endogenous CB receptor agonist (in water-soluble emulsion)

别名： Arachidonylethanolamide,AEA

化学名： N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide

说明书

引用文献 (6)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Anandamide (in Tocrisolve™ 100)

Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see Tocrisolve^TM 100, Cat. No. 1684). K_i values are 89 and 371 nM for CB₁ and CB₂ receptors respectively; EC₅₀ values are 18, 31 and 27 nM at GPR55, CB₁ and CB₂ respectively; pK_i = 5.68 for rVR1. Also blocks TNF-α-induced NF-kB activation via direct inhibition of IKK.

Available as the pure oil dissolved in ethanol, Anandamine. Tocrisolve Control also available.

技术数据 for Anandamide (in Tocrisolve™ 100)

分子量	347.54
公式	C₂₂H₃₇NO₂
储存	Store at +4°C
CAS Number	94421-68-8
PubChem ID	5281969
InChI Key	LGEQQWMQCRIYKG-DOFZRALJSA-N
Smiles	O=C(NCCO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Anandamide (in Tocrisolve™ 100)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Anandamide (in Tocrisolve™ 100)

参考文献是支持产品生物活性的出版物。

Gardiner et al (2002) Complex regional haemodynamic effects of anandamide in conscious rats. Br.J.Pharmacol. 135 1889 PMID: 11959791

Kagaya et al (2002) Characterization of the anandamide-induced depolarization of guinea-pig isolated vagus nerve. Br.J.Pharmacol. 137 39 PMID: 12183329

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884

Ross et al (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 132 631 PMID: 11159715

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

Sancho et al (2003) Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 63 429 PMID: 12527815

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关键词: Anandamide (in Tocrisolve 100), Anandamide (in Tocrisolve 100) supplier, Endogenous, CB, agonist, water-soluble, emulsion, vanilloid, Cannabinoids, Non-Selective, Receptors, Vanillioid, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, cb2r, cb1r, Arachidonylethanolamide, AEA, Non-selective, 1017, Tocris Bioscience

6 篇 Anandamide (in Tocrisolve™ 100) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Anandamide (in Tocrisolve™ 100) 的部分引用包括：

Mair et al (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. Br J Pharmacol 161 176 PMID: 20718749

Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. Cell Death Differ 26 9666 PMID: 16988037

Diniz et al (2019) Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ 7 e6493 PMID: 30809460

Ho et al (2008) 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol 155 837 PMID: 18695637

Ho and Gardiner (2009) Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. Cereb Cortex 156 94 PMID: 19133994

Movsesyan et al (2004) Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways. Br J Pharmacol 11 1121 PMID: 15375383