Andrographolide

Name: Andrographolide
Brand: Tocris Bioscience
SKU: 4626

Cat. No. 4626 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4626 has been discontinued.

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说明： Inhibits NFκB; blocks androgen receptor (AR) expression

化学名： (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone

纯度： ≥99% (HPLC)

说明书

引用文献

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for Andrographolide

Andrographolide is an inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC₅₀ = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.

技术数据 for Andrographolide

分子量	350.45
公式	C₂₀H₃₀O₅
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	5508-58-7
PubChem ID	452937
InChI Key	BOJKULTULYSRAS-UQZPWQSVSA-N
Smiles	C=C1CC[C@@]([C@@](CO)(C)[C@H](O)CC3)([H])[C@]3(C)[C@@H]1C/C=C2[C@H](O)COC/2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Andrographolide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Andrographolide

参考文献是支持产品生物活性的出版物。

Liu et al (2011) Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2 151 PMID: 21779488

Burgos et al (2005) Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta.Med. 71 429 PMID: 15931581

Guan et al (2012) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br.J.Pharmacol. [Epub ahead of print] PMID: 23146110

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关键词: Andrographolide, Andrographolide supplier, nfkb, nrf2, inhibitors, inhibits, androgen, receptors, AR, expression, ifng, ifngamma, interferons, immunosuppressants, NF-kB/IkB, Androgen, Receptor, Nrf2, 4626, Tocris Bioscience

篇 Andrographolide 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Andrographolide 的引用文献。