Ani 9

Cat. No. 6076 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

化学名： 2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ani 9

Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC₅₀ = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).

技术数据 for Ani 9

分子量	332.78
公式	C₁₇H₁₇ClN₂O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	356102-14-2
PubChem ID	9556542
InChI Key	KDALDZRKOBJXIE-VXLYETTFSA-N
Smiles	COC1=C(C=CC=C1)/C=N/NC(COC2=C(C=C(C=C2)Cl)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ani 9

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	33.28	100

制备储备液 for Ani 9

以下数据基于产品分子量 332.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3 mL	15.02 mL	30.05 mL
5 mM	0.6 mL	3 mL	6.01 mL
10 mM	0.3 mL	1.5 mL	3 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for Ani 9

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ani 9

参考文献是支持产品生物活性的出版物。

Seo et al (2016) Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11 e0155771 PMID: 27219012

If you know of a relevant reference for Ani 9, please let us know.

按标靶查看相关产品

关键词: Ani 9, Ani 9 supplier, Ani9, Potent, TMEM16A, Anoctamin-1, blockers, transmembrane, protein, 16A, CaCC, blocks, calcium-activated, chloride, channels, ANO1, Ca2+-Activated, Chloride, Channels, 6076, Tocris Bioscience

2 篇 Ani 9 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ani 9 的部分引用包括：

Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079

Heikki et al (2021) ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma. Cancers (Basel) 13 PMID: 33803266

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