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Submit ReviewAPC 366
说明： Tryptase inhibitor
化学名： N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
纯度： ≥95% (HPLC)
生物活性 for APC 366
APC 366 is a selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.
技术数据 for APC 366
| 分子量 | 440.5 |
| 公式 | C22H28N6O4 |
| 序列 | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 158921-85-8 |
| PubChem ID | 177340 |
| InChI Key | SKYWIMYOGAWOMB-IRXDYDNUSA-N |
| Smiles | OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for APC 366
| 溶解性 | Soluble to 5 mg/ml in 20% ethanol / water |
产品说明书 for APC 366
参考文献 for APC 366
参考文献是支持产品生物活性的出版物。
He et al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289 PMID: 9655871
Barrios et al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295 PMID: 9877219
He et al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119 PMID: 14722328
Numerof et al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6 811
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关键词: APC 366, APC 366 supplier, Tryptase, inhibitors, inhibits, mast, cell, Proteases, Proteinases, PAR, Receptors, Protease-Activated, proteinase-activated, APC366, Other, 2511, Tocris Bioscience
1 篇 APC 366 的引用文献
引用文献是使用了 Tocris 产品的出版物。 APC 366 的部分引用包括：
Matsuda et al (2015) Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. Am J Transl Res 2015 635041 PMID: 26539519
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