Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewApocynin
说明： NADPH-oxidase inhibitor
化学名： 4'-Hydroxy-3'-methoxyacetophenone
纯度： ≥99% (HPLC)
生物活性 for Apocynin
Apocynin is an NADPH oxidase inhibitor. Demonstrates anti-inflammatory properties in a mouse model of carrageenan-induced pleurisy. Apocynin is bioactivated by intracellular peroxidases; acts as an antioxidant in endothelial cells and vascular smooth muscle cells.
化合物库 for Apocynin
Apocynin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Apocynin
| 分子量 | 166.17 |
| 公式 | C9H10O3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 498-02-2 |
| PubChem ID | 2214 |
| InChI Key | DFYRUELUNQRZTB-UHFFFAOYSA-N |
| Smiles | CC(C1=CC(OC)=C(O)C=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Apocynin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 16.62 | 100 | |
| ethanol | 16.62 | 100 |
制备储备液 for Apocynin
以下数据基于产品分子量 166.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.02 mL | 30.09 mL | 60.18 mL |
| 5 mM | 1.2 mL | 6.02 mL | 12.04 mL |
| 10 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 50 mM | 0.12 mL | 0.6 mL | 1.2 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Apocynin
参考文献 for Apocynin
参考文献是支持产品生物活性的出版物。
Stolk et al (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am.J.Respir.Cell Mol.Biol. 11 95 PMID: 8018341
Impellizzeri et al (2011) Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem.Pharmacol. 81 636 PMID: 21147071
Heumüller et al (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51 211 PMID: 18086956
If you know of a relevant reference for Apocynin, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Apocynin, Apocynin supplier, Apocynin, NADPH, oxidases, inhibitors, inhibits, leukocytes, anti-inflammatory, peroxidases, Oxidase, 4663, Tocris Bioscience
11 篇 Apocynin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Apocynin 的部分引用包括：
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624
Kyung-Sun et al (2021) Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling. Cancers (Basel) 13 PMID: 33920802
Rita et al (2018) Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine. Glia 66 2353-2365 PMID: 30394585
Kyung-Sun et al (2022) Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling Pathway. Antioxidants (Basel) 11 PMID: 35453328
Chiao et al (2022) Interleukin-1 receptor antagonism leads to improved anaemia in a murine model of sickle cell disease and is associated with reduced ex vivo platelet-mediated erythrocyte sickling. Br J Haematol 196 1040-1051 PMID: 34786709
Minsoo et al (2019) Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation. Cell Rep 28 2923-2938.e8 PMID: 31509752
Rebecca L et al (2019) NADPH Oxidase Mediates Membrane Androgen Receptor-Induced Neurodegeneration. Endocrinology 160 947-963 PMID: 30811529
Richard S et al (2020) Controlled Feeding of an 8-d, High-Dairy Cheese Diet Prevents Sodium-Induced Endothelial Dysfunction in the Cutaneous Microcirculation of Healthy, Older Adults through Reductions in Superoxide. J Nutr 150 55-63 PMID: 31504721
Michaeli et al (2017) Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment. Oncoimmunology 6 e1356965 PMID: 29147615
Hassler et al (2014) Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. Int J Mol Med 131 413 PMID: 25051888
您是否知道使用了 Tocris Apocynin 的优秀论文？ 请告知我们.
Apocynin 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Apocynin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Apocynin.
By
Anonymous on 01/10/2018
分析类型： Ex Vivo
种属： Rat
细胞系/组织： brain slice
Apocynin is a NADPH oxidase inhibitor. It blocks NADPH oxidase in rat brain slice at 1mM.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.