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Submit ReviewApoptosis Activator 2
说明： Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
化学名： 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
纯度： ≥99% (HPLC)
生物活性 for Apoptosis Activator 2
Apoptosis Activator 2 is an apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).
技术数据 for Apoptosis Activator 2
| 分子量 | 306.14 |
| 公式 | C15H9Cl2NO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 79183-19-0 |
| PubChem ID | 1901244 |
| InChI Key | KGRJPLRFGLMQMV-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Apoptosis Activator 2
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 1.53 | 5 | |
| DMSO | 30.61 | 100 |
制备储备液 for Apoptosis Activator 2
以下数据基于产品分子量 306.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.27 mL | 16.33 mL | 32.66 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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产品说明书 for Apoptosis Activator 2
参考文献 for Apoptosis Activator 2
参考文献是支持产品生物活性的出版物。
Alavian et al (2009) Elevtaed p75NTR expression causes death of engrailed-deficient midbrain DArgic neurons by Erk1/2 suppression. Neural Dev. 4 11 PMID: 19291307
Jayaraman and Pike (2009) Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. J.Neuroendocrinol. 21 77 PMID: 19094096
Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.USA 100 7533
If you know of a relevant reference for Apoptosis Activator 2, please let us know.
关键词: Apoptosis Activator 2, Apoptosis Activator 2 supplier, Promotes, apoptosome, formation, activates, caspase-9/caspase-3, pathway, induces, apoptosis, Selective, Inducer, Apoptosis, Activator2, Caspases, Inducers, 2098, Tocris Bioscience
2 篇 Apoptosis Activator 2 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Apoptosis Activator 2 的部分引用包括：
Pan et al (2016) SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res 26 190 PMID: 26768768
Stankiewicz et al (2005) Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. PLoS One 280 38729 PMID: 16172114
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Apoptosis Activator 2 的评论
平均评分: 5 (Based on 1 Review.)
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Apoptosis Activator 2 was used to induce apoptosis in epidermal cancer cell line: Works ideally.
By
Anonymous on 02/13/2019
种属： Human
Apoptosis Activator 2 was used to induce apoptosis in epidermal cancer cell line.Works great and gives publishable outcome.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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