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AR 420626

Cat. No. 6163 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： FFA3 agonist
化学名： N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AR 420626

AR 420626 is a FFA3 agonist (pEC50 = 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.

化合物库 for AR 420626

AR 420626 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AR 420626

分子量 417.29
公式 C21H18Cl2N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1798310-55-0
PubChem ID 11509934
InChI Key BYLWSJCOCFUZDH-UHFFFAOYSA-N
Smiles CC1=C(C(NC2=C(C=CC(Cl)=C2)Cl)=O)C(C3=C(N1)CCCC3=O)C4=CC=CO4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AR 420626

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.86 50

制备储备液 for AR 420626

以下数据基于产品分子量 417.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.79 mL 23.96 mL 47.93 mL
2.5 mM 0.96 mL 4.79 mL 9.59 mL
5 mM 0.48 mL 2.4 mL 4.79 mL
25 mM 0.1 mL 0.48 mL 0.96 mL

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参考文献 for AR 420626

参考文献是支持产品生物活性的出版物。

Hudson et al (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands. Mol Pharmacol. 86 200 PMID: 24870406

Kaji et al (2017) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol.Motil. 30 PMID: 28714277

If you know of a relevant reference for AR 420626, please let us know.

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关键词: AR 420626, AR 420626 supplier, AR420626, free, fatty, acid, FFAR, FFA3, agonist, agonism, short, chain, SCFA, Free, Fatty, Acid, Receptors, 6163, Tocris Bioscience

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