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Submit ReviewAR-R 17779 hydrochloride
Discontinued Product
3964 has been discontinued.
说明： Selective α7 nAChR agonist
化学名： (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
生物活性 for AR-R 17779 hydrochloride
Selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for AR-R 17779 hydrochloride
| 分子量 | 218.68 |
| 公式 | C9H14N2O2.HCl |
| 储存 | Desiccate at RT |
| CAS Number | 178419-42-6 |
| PubChem ID | 9859263 |
| InChI Key | XGLBLUBBDSJBIU-FVGYRXGTSA-N |
| Smiles | O=C(NC3)O[C@@]13CN2CCC1CC2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AR-R 17779 hydrochloride
参考文献 for AR-R 17779 hydrochloride
参考文献是支持产品生物活性的出版物。
Grottick et al (2000) Evidence that nicotinic α7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J.Pharmacol.Exp.Ther. 294 1112 PMID: 10945867
Mullen et al (2000) (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. J.Med.Chem. 43 4045 PMID: 11063601
Huang et al (2010) Activation of presynaptic α7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br.J.Pharmacol. 159 554 PMID: 20105181
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2 篇 AR-R 17779 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AR-R 17779 hydrochloride 的部分引用包括：
Cao et al (2019) α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin. Front Immunol 10 1063 PMID: 31143190
Cortes et al (2017) α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep 7 10645 PMID: 28878260
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