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View all CDK4 Subfamily (CDK4 & CDK6) products.Arcyriaflavin A is a potent cyclin-dependent kinase 4 (cdk4) inhibitor (IC50 value reported between 60 and 190 nM). Displays activity at other cdks in the sub-micromolar range. Also potently inhibits CaM kinase II (IC50 = 25 nM). Inhibits human cytomegalovirus (HCMV) replication in vitro.
Arcyriaflavin A is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
分子量 | 325.32 |
公式 | C20H11N3O2 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 118458-54-1 |
PubChem ID | 5327723 |
InChI Key | KAJXOWFGKYKMMZ-UHFFFAOYSA-N |
Smiles | O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Slater et al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067 PMID: 10428375
Zhu et al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231 PMID: 12657252
Sanchez-Martinez et al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835 PMID: 14552791
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
关键词: Arcyriaflavin A, Arcyriaflavin A supplier, Potent, CaM, Kinase, II, cdk4, cyclin, D1, inhibitors, inhibits, Antiviral, agent, anti-HCMV, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Cdk, Cyclin-Dependent, Ca2+, Binding, modulators, Calmodulin, Calcium, Signaling, Signalling, ArcyriaflavinA, Cyclin-dependent, Cytomegalovirus, CDK4, Subfamily, 2457, Tocris Bioscience
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Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs as assessed using the 5-bromo-2-deoxyuridine (BrdU) and methylthiazoletetrazolium bromide (MTT) assays, and vascular endothelial growth factor (VEGF) ELISA.