主页 / 药理学 / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / CDK4 Subfamily (CDK4 & CDK6) / CDK4 Subfamily Inhibitors / Arcyriaflavin A

Arcyriaflavin A

Cat. No. 2457 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2457 has been discontinued.

View all CDK4 Subfamily (CDK4 & CDK6) products.
说明： Potent cdk4 inhibitor; also potently inhibits CaM kinase II; antiviral
化学名： 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Arcyriaflavin A

Arcyriaflavin A is a potent cyclin-dependent kinase 4 (cdk4) inhibitor (IC50 value reported between 60 and 190 nM). Displays activity at other cdks in the sub-micromolar range. Also potently inhibits CaM kinase II (IC50 = 25 nM). Inhibits human cytomegalovirus (HCMV) replication in vitro.

化合物库 for Arcyriaflavin A

Arcyriaflavin A is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Arcyriaflavin A

分子量 325.32
公式 C20H11N3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 118458-54-1
PubChem ID 5327723
InChI Key KAJXOWFGKYKMMZ-UHFFFAOYSA-N
Smiles O=C1NC(=O)C2=C1C1=C(NC3=CC=CC=C13)C1=C2C2=C(N1)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Arcyriaflavin A

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Arcyriaflavin A

参考文献是支持产品生物活性的出版物。

Slater et al (1999) Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. Bioorg.Med.Chem. 7 1067 PMID: 10428375

Zhu et al (2003) Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 1231 PMID: 12657252

Sanchez-Martinez et al (2003) Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg.Med.Chem.Lett. 13 3835 PMID: 14552791

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

按标靶查看相关产品

按产品操作查看相关产品

查看全部 CDK4 Subfamily Inhibitors

关键词: Arcyriaflavin A, Arcyriaflavin A supplier, Potent, CaM, Kinase, II, cdk4, cyclin, D1, inhibitors, inhibits, Antiviral, agent, anti-HCMV, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Cdk, Cyclin-Dependent, Ca2+, Binding, modulators, Calmodulin, Calcium, Signaling, Signalling, ArcyriaflavinA, Cyclin-dependent, Cytomegalovirus, CDK4, Subfamily, 2457, Tocris Bioscience

篇 Arcyriaflavin A 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Arcyriaflavin A 的引用文献。

Arcyriaflavin A 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used Arcyriaflavin A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs.
By Anonymous on 12/24/2019
种属： Human

Arcyriaflavin A was observed for its activity on cell viability, proliferation, and angiogenesis of ECSCs as assessed using the 5-bromo-2-deoxyuridine (BrdU) and methylthiazoletetrazolium bromide (MTT) assays, and vascular endothelial growth factor (VEGF) ELISA.

review image