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说明： Selective inhibitor of MMP-2
化学名： 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
纯度： ≥99% (HPLC)
生物活性 for ARP 100
ARP 100 is a selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
技术数据 for ARP 100
| 分子量 | 364.42 |
| 公式 | C17H20N2O5S |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 704888-90-4 |
| PubChem ID | 10044321 |
| InChI Key | PHGLPDURIUEELR-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)CC(NO)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ARP 100
参考文献 for ARP 100
参考文献是支持产品生物活性的出版物。
Rossello et al (2004) New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg.Med.Chem. 12 2441 PMID: 15080939
Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784
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关键词: ARP 100, ARP 100 supplier, Selective, inhibitors, inhibits, MMP-2, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, ARP100, 2621, Tocris Bioscience
3 篇 ARP 100 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ARP 100 的部分引用包括：
Hensley et al (2012) Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice. Neoplasia 14 451 PMID: 22787427
Chetty et al (2010) MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Mol Biol Cell 127 1081 PMID: 20027628
Ji et al (2015) WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br J Cancer 113 921 PMID: 26291058
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.